https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47704 Wed 25 Jan 2023 10:34:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17021 Wed 11 Apr 2018 17:14:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15023 Wed 11 Apr 2018 16:31:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17101 Wed 11 Apr 2018 09:35:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14098 Wed 11 Apr 2018 09:13:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33905 Tnfa, mitogen-activated protein kinase 8 (Mapk8/Jnk1), and growth differentiation factor 9 (Gdf9) (P < 0.05). Mass spectrometry and cell signaling pathway analysis indicated upregulation of cellular pathways associated with acute phase signaling, and cellular survival and assembly. Apoptosis assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling indicated significantly increased positive staining in the ovaries of LPS-treated neonates. These findings suggest that increased proinflammatory signaling within the neonatal ovary may be responsible for the LPS-induced depletion of the primordial follicle pool. These findings also have implications for female reproductive health, as the ovarian reserve is a major determinate of female reproductive longevity.]]> Wed 09 Feb 2022 15:58:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30359 Wed 04 Sep 2019 09:47:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43297 Thu 15 Sep 2022 12:51:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32656 Thu 05 Jul 2018 10:55:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20802 h1 differentiator and leukocyte activator. Ample studies showed suppression of IL-12 production by numerous stress factors, including prostaglandins, catecholamines, glucocorticoids, and opioids, but did so in vitro and in the context of artificial leukocyte activation, not simulating the in vivo setting. In a recent study we reported in vivo suppression of plasma IL-12 levels by behavioral stress and surgery. The current study aims to elucidate neuroendocrine mechanisms underlying this phenomenon in naïve F344 rats. To this end, both adrenalectomy and administration of specific antagonists were used, targeting the aforementioned stress factors. The results indicated that corticosterone and prostaglandins are prominent mediators of the IL-12-suppressing effects of stress and surgery, apparently through directly suppressing leukocyte IL-12 production. Following surgery, endogenous prostaglandins exerted their effects mainly through elevating corticosterone levels. Importantly, stress-induced release of epinephrine or opioids had no impact on plasma IL-12 levels, while pharmacological administration of epinephrine reduced plasma IL-12 levels by elevating corticosterone levels. Last, a whole blood in vitro study indicated that prostaglandins and corticosterone, but not epinephrine, suppressed IL-12 production in non-stimulated leukocytes, and only corticosterone did so in the context of CpG-C-induced IL-12 production. Overall, the findings reiterate the notion that results from in vitro or pharmacological in vivo studies cannot indicate the effects of endogenously released stress hormones under stress/surgery conditions. Herein, corticosterone and prostaglandins, but not catecholamines or opioids, were key mediators of the suppressive effect of stress and surgery on in vivo plasma IL-12 levels in otherwise naïve animals.]]> Sat 24 Mar 2018 08:05:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20532 Sat 24 Mar 2018 08:02:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19648 Sat 24 Mar 2018 08:01:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21584 Sat 24 Mar 2018 08:00:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17701 Sat 24 Mar 2018 07:57:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26459 Sat 24 Mar 2018 07:27:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30987 Mon 20 Nov 2023 14:18:12 AEDT ]]>